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Publisher's Summary

A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril.
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers and will help address the world's hunger crisis. Yet even the tiniest changes to DNA could have myriad unforeseeable consequences - to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create "better" humans. Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?
©2017 Jennifer A. Doudna and Samuel H. Sternberg (P)2017 Audible, Inc.
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Customer Reviews

Most Helpful

By DC Mike on 09-01-17

An easily digestible intro to the future...

Maybe it was driven by my personal curiosity but I found this to be an excellent intro to a topic that I've only encountered in exaggerated news clips or poorly written internet blog ramblings.

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4 of 4 people found this review helpful

By Philomath on 06-17-17

In to the abyss we ascend, a scary future

Would you listen to A Crack in Creation again? Why?

Probably not

Who was your favorite character and why?


What about Erin Bennett’s performance did you like?


Was there a moment in the book that particularly moved you?

The whole idea shook me not just moved me

Any additional comments?

This book is a must read for everyone. Humanity is on the cusp of changing itself forever and most don't even know it.

I will ignore the mistakes and unintended consequences of the fascinating CRISPR technology, which are scarier and more prevalent than any technology humans have ever created, and let's pretend everything goes as planned, a highly unlikely scenario.

CRISPR technology is basically the editing of genes with what appears to be the at most accuracy, and it is easier and cheaper than pretty much any other important technology man has recently created.

Creating a mouse that glows in the dark, a pig that is the size of a pet dog, a fish which grows legs are things that have already been achieved. Eliminating heritable disease will be next without a doubt, and what after that? Forget a pretty blue eyed child, or a tall muscular athlete, which I'm sure is coming to a theatre next to you soon.

Let's use our imagination, a larger brain, more memory, more stamina, less sleep, high IQ, a human that has gills and can breath underwater and go down the near endless list of living DNA and pick your choice.

At first glance I think, let this not happen, STOP it right now, then I realise the cat is out of the bag, Pandora's box has been opened. It is the ultimate weapon for domination that has all the hallmarks of Eugenics on steroids.

To quote Steven Pinker let's hope "the better nature of our angels" evolves quickly enough to create future humans with compassion and tolerance. The author, probably a great scientist, is an optimist. I truly hope she's right, otherwise this could be a good explanation to Fermi's Paradox. This could potentially be the last mistake humankind makes. Since the next one if we are lucky will be made by an edited human animal that will need a new name.

Fascinating, incredible and scary science, and not necessarily in this order. Highly recommended for those who want to be spooked.

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17 of 20 people found this review helpful

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Customer Reviews

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By Craig on 11-05-17

Outstanding Science !

Whilst the science of CRISPR will change everything....and I mean everything, this book is superb at putting the case for both the technical issues and the societal.

One of the best books I have read in a long time!

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By M. Griffiths on 08-15-17

Gene editing introduction

From the horse's mouth, this book runs thru the discovery of truly transformational biology. Basic concepts are well explained for the uninitiated and the story is both incredibly important and interesting. The author's presentation of her work was not unlikeable and seemed fair - she has been accused of claiming all the credit.
Why not 5 stars? It is a little repetitive and an accompanying pdf is invaluable for this type of book.

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Customer Reviews

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By Heinrich Ferreira on 02-15-18

Simply a remarkable book

I simply loved this book. Have not read a more comprehensive coverage and heard a more authoritative review of gene editing than this.

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By Alex Sims on 02-05-18

Overall very interesting

Some repitition but overall a fascinating overview, would have been good to touch on some of the work being done at competing universities

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