In this issue: COMMENT "Putin and the Exile", by David Remnick: Sergei Guriev in Paris. THE TALK OF THE TOWN "Martians", by Reeves Wiedman: An open application to travel to Mars. THE FINANCIAL PAGE "Biotech’s Hard Bargain", by James Surowiecki: Gilead, drug prices, and profits. ONWARD AND UPWARD WITH THE ARTS "Pixel Perfect", by Margaret Talbot: Digitally cloning actors. LIFE AND LETTERS "The Poet’s Hand", by Adam Gopnik: Searching for Shakespeare’s objects. THE ART WORLD "Shock Artist", by Peter Schjeldahl: A Sigmar Polke retrospective. ON TELEVISION "Cheaper by the Dozen", by Emily Nussbaum: A review of Orphan Black.